RESUMO
3Beta,11beta-dihydroxy-9alpha-fluor-5alpha-androstane-17-one (2), 3beta-acetoxy-9alpha-fluor-11beta-hydroxy-5alpha-androstane-17-one (3), 3beta-acetoxy-9alpha-fluor-11beta,17beta-dihydroxy-5alpha-androstane (4), 3beta,17beta-diacetoxy-9alpha-fluor-11beta-hydroxy-5alpha-androstane (5), 3beta-acetoxy-9alpha-fluor-11beta-hydroxy-5alpha-androstane 17beta-propionate (6), 3beta-acetoxy-9alpha-fluor-11beta-hydroxy-5alpha-androstane 17beta-enanthate (7), 3beta-acetoxy-9alpha-fluor-11beta-hydroxy-5alpha-androstane 17beta-isobutyrate (8) were synthesized in the present study. Compounds 2 and 8 exhibited higher anabolic activity than the rest of the synthesized compounds. The structure of all these newly synthesized compounds was confirmed by analytic spectral data (mass, (1)H NMR and (13)C NMR).
Assuntos
Anabolizantes/química , Anabolizantes/farmacologia , Androgênios/química , Androgênios/farmacologia , Androstanos/química , Androstanos/farmacologia , Anabolizantes/síntese química , Androgênios/síntese química , Androstanos/síntese química , Animais , Flúor/química , Flúor/farmacologia , Masculino , Músculos/efeitos dos fármacos , Tamanho do Órgão/efeitos dos fármacos , Próstata/efeitos dos fármacos , Ratos , Ratos Wistar , Glândulas Seminais/efeitos dos fármacosRESUMO
Los modelos animales de dolor han permitido en las últimas décadas un salto en las investigaciones de su neurobiología, pero los sistemas biológicos no son exactos y haymúltiples factores que pueden determinar resultados contradictorios. Las dificultades se exacerban al diseñar modelos en los que se aplique la electroacupuntura, pues existe una variabilidad paramétrica para la liberación de mediadores, tambiénpara la respuesta de los sistemas bioquímicos manipulados en condiciones fisiológicas o patológicas, marcadainfluencia de la Analgesia Inducida por Estrés (SIA), entreotras. Nuestro propósito es analizar críticamente algunos experimentos recientes en este campo, de autores que han enfrentado estas dificultades y aún así, han aportado elementosimportantes para el esclarecimiento de los mecanismos involucradosen la analgesia acupuntural (AU)
Animal models of pain have permitted in the last decadesimportant advances in neurobiologic research, but biologicalsystems are not exact and there are multiple factors that canlead to contradictory results. Those difficulties are exacerbatedin models addressed to electroacupuncture treatment procedures,as a parametric variability exists for the liberation of mediators, also for the response of biochemical systems manipulatedunder physiologic or pathological conditions, amongother the influence of the stress induced analgesia (SIA). Ourpurpose is to critically analyze some recent experiments in thisfield, from authors that have faced these difficulties and stillhave provided important elements for the clarification of themechanisms involved in acupuncture analgesia (AU)
